Desferrioxamine is both an iron chelator and a lysosomotropic amine
نویسندگان
چکیده
منابع مشابه
Desferrioxamine and membrane oxidation: radical scavenger or iron chelator?
meter affecting the efficiency of the whole process is the chemical structure of the drug molecule. The saturated or unsaturated character o f PL acyl chains seems t o play a secondary role. T h e reason for this low incidence could he thc high content of cholesterol in the DRV preparations. It is well known that this molecule modulates the fluidity of the bilayers, having a dual behaviour, dep...
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The effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negati...
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Iron chelators have been employed in various studies aimed at evaluating the relationship between the iron status of the host and the development of infection. In the present study, the effects of benznidazole (BZ) therapy in combination with the iron chelator desferrioxamine (DFO) on the development of infection in mice inoculated with Trypanosoma cruzi Y strain have been investigated. Infecte...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a49-d